Article

Aqueous Humor Liquid Biopsy Enables Multi-Omics Tumor Profiling and Methylation-Based Machine-Learning Stratification of Retinoblastoma

2026-07-13

Abstract excerpt

Primary tumor biopsy in retinoblastoma carries an unacceptable risk of extraocular dissemination. As a result, children treated with eye-sparing approaches currently lack access to tumor-derived genomic information at diagnosis, limiting accurate risk stratification, preventing subtype-guided therapy, and obscuring insight into tumor evolution during conservative treatment. Aqueous humor (AH) liquid biopsy has eme...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 84466272-ba9a-5df7-8109-31f29933a83c
DOI: 10.64898/2026.07.09.26357661

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Aqueous Humor Liquid Biopsy Enables Multi-Omics Tumor Profiling and Methylation-Based Machine-Learning Stratification of RetinoblastomaDOI 10.64898/2026.07.09.26357661Read

Characterizing DNA methylation signatures of retinoblastoma using aqueous humor liquid biopsySemantic proximity Read

Establishing the Clinical Utility of ctDNA Analysis for Diagnosis, Prognosis, and Treatment Monitoring of Retinoblastoma: The Aqueous Humor Liquid BiopsySemantic proximity Read

Comprehensive Somatic Copy Number Analysis Using Aqueous Humor Liquid Biopsy for RetinoblastomaSemantic proximity Read

The Potential of Aqueous Humor Sampling in Diagnosis, Prognosis, and Treatment of RetinoblastomaSemantic proximity Read

Retinoblastoma: Aqueous humor liquid biopsySemantic proximity Read

Retinoblastoma: Molecular Evaluation of Tumor Samples, Aqueous Humor, and Peripheral Blood Using a Next-Generation Sequence PanelSemantic proximity Read

Simultaneous identification of clinically relevant RB1 mutations and copy number alterations in aqueous humor of retinoblastoma eyes.Semantic proximity Read

Aqueous Humor as a Liquid Biopsy for Retinoblastoma: Clear Corneal Paracentesis and Genomic AnalysisSemantic proximity Read

Simultaneous Copy Number Alteration and Single-Nucleotide Variation Analysis in Matched Aqueous Humor and Tumor Samples in Children with RetinoblastomaSemantic proximity Read

Cell‐free DNA profiling in retinoblastoma patients with advanced intraocular disease: An MSKCC experienceSemantic proximity Read

Liquid biopsy in Retinoblastoma: A review.Semantic proximity Read

Aqueous Humor Liquid Biopsy as a Companion Diagnostic for Retinoblastoma: Implications for Diagnosis, Prognosis, and Therapeutic Options: Five Years of ProgressSemantic proximity Read