Article

Computational identification of novel Kir6 channel inhibitors

2019-02-03

Abstract excerpt

KATP channels consist of four Kir6.x pore–forming subunits and four regulatory sulfonylurea receptor (SUR) subunits. These channels couple the metabolic state of the cell to membrane excitability and play a key role in physiological processes such as insulin secretion in the pancreas, protection of cardiac muscle during ischemia and hypoxic vasodilation of arterial smooth muscle cells. Abnormal channel function re...

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Literature Corpus work: 843fb565-ecc8-5d17-bd99-6bb45f28ba6b
DOI: 10.1101/539460

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