Article

<i>De novo</i> recovery of Ghana virus, an African bat Henipavirus, reveals differential tropism and attenuated pathogenicity compared to Nipah virus

2025-10-08

Abstract excerpt

<h4>Summary</h4> Henipaviruses (HNVs) like Nipah (NiV) and Hendra (HeV) viruses represent severe zoonotic threats. Ghana virus (GhV), identified in 2012, is the only African bat henipavirus with a near-complete genome assembly. However, without isolates in culture, GhV biology, pathogenicity, and zoonotic potential remain poorly understood. Using reverse genetics, we recovered a full-length infectious clone of Gh...

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Literature Corpus work: 842316a3-3e89-5e4b-9687-5617c929b97d
DOI: 10.1101/2025.10.08.679836

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