Article

Current status of immunodeficient mouse models as substitutes to reduce cat and dog use in heartworm preclinical research

2024-09-11

Abstract excerpt

Chemoprophylactic prevention of veterinary heartworm disease in companion animals, caused by the vector-borne nematode parasite Dirofilaria immitis, is a multi-billion-dollar global market. Experimental use of cats and dogs in preclinical heartworm drug testing is increasing due to evolving drug-resistance to frontline macrocyclic lactones and renewed investment in alternative preventative drug research. We and o...

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Identifiers and source

Literature Corpus work: 82519104-25c6-5125-b4a8-4875ddbbe81f
DOI: 10.12688/f1000research.149854.2

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