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The allelic rice immune receptor Pikh confers extended resistance to strains of the blast fungus through a single polymorphism in the effector binding interface

2020-09-05

Abstract excerpt

Arms race co-evolution drives rapid adaptive changes in pathogens and in the immune systems of their hosts. Plant intracellular NLR immune receptors detect effectors delivered by pathogens to promote susceptibility, activating an immune response that halts colonization. As a consequence, pathogen effectors evolve to escape immune recognition and are highly variable. In turn, NLR receptors are one of the most diver...

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Literature Corpus work
8200b004-e6e7-53b1-829a-a90c4dfd771a
DOI
10.1101/2020.09.05.284240
Open publication

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The allelic rice immune receptor Pikh confers extended resistance to strains of the blast fungus through a single polymorphism in the effector binding interfaceDOI 10.1101/2020.09.05.284240
The allelic rice immune receptor Pikh confers extended resistance to strains of the blast fungus through a single polymorphism in the effector binding interface.Semantic proximity
Effector target-guided engineering of an integrated domain expands the disease resistance profile of a rice NLR immune receptorSemantic proximity
The Piks allele of the NLR immune receptor Pik breaks the recognition of AvrPik effectors of rice blast fungus.Semantic proximity
Two NLR immune receptors acquired high-affinity binding to a fungal effector through convergent evolution of their integrated domain.Semantic proximity
Cross-reactivity of a rice NLR immune receptor to distinct effectors from the blast pathogen leads to partial disease resistanceSemantic proximity
The blast pathogen effector AVR-Pik binds and stabilizes rice heavy metal-associated (HMA) proteins to co-opt their function in immunitySemantic proximity
Multiple variants of the blast fungus effector AVR-Pik bind the HMA domain of the rice protein OsHIPP19 with high affinitySemantic proximity
Bioengineering a plant NLR immune receptor with a robust binding interface towards a conserved fungal pathogen effectorSemantic proximity
Protein engineering expands the effector recognition profile of a rice NLR immune receptorSemantic proximity
Multiple variants of the fungal effector AVR-Pik bind the HMA domain of the rice protein OsHIPP19, providing a foundation to engineer plant defense.Semantic proximity
Allelic compatibility in plant immune receptors facilitates engineering of new effector recognition specificitiesSemantic proximity
Functional diversification gave rise to allelic specialization in a rice NLR immune receptor pair.Semantic proximity
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