Article

Identification of a link between splicing and endoplasmic reticulum proteostasis

2023-09-29

Abstract excerpt

The role of general splicing in endoplasmic reticulum (ER)-proteostasis remains poorly understood. Here, we identify SNRPB, a component of the spliceosome, as a novel regulator of export from the ER. Mechanistically, SNRPB regulates the splicing of components of the ER export machinery, including Sec16A, a regulator of ER exit sites. Loss of function of SNRPB is causally linked to cerebro-costo-mandibular syndrome...

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Literature Corpus work: 8110fb16-9c01-53d9-8287-cd7d3057528b
DOI: 10.1101/2023.09.28.559974

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