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Discovery of a novel <i>Trichuris</i> species, <i>T. incognita</i> , with low sensitivity to albendazole-ivermectin treatment in Côte d’Ivoire patients, identified through fecal DNA metabarcoding

2024-07-06

Abstract excerpt

Albendazole-ivermectin combination therapy is a promising alternative to benzimidazole monotherapy for Trichuris trichiura control. We used fecal DNA metabarcoding to genetically characterize Trichuris populations in patients from a clinical trial showing lower albendazole-ivermectin efficacy in Côte d’Ivoire (ERR below 70%) than in Lao PDR and Tanzania (ERR above 98%). ITS-1 and ITS-2 rDNA metabarcoding reveale...

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Literature Corpus work
8105992b-00db-5d6f-baa4-06de658c932f
DOI
10.1101/2024.07.04.602123
Open publication

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Discovery of a novel <i>Trichuris</i> species, <i>T. incognita</i> , with low sensitivity to albendazole-ivermectin treatment in Côte d’Ivoire patients, identified through fecal DNA metabarcodingDOI 10.1101/2024.07.04.602123
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