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Cytoplasmic staining of T cell receptor components enables efficient assessment of lineage and clonality in surface CD3-negative T cell neoplasms

2026-06-04

Abstract excerpt

<h4>ABSTRACT</h4> Flow cytometry can establish T cell clonality by detecting a restricted expression pattern of the T cell receptor (TCR) β constant region (TRBC), expressed in association with CD3. However, T cell neoplasms frequently lose surface expression of the CD3/TCR complex, posing a challenge to demonstrating T cell lineage and clonality. To address this challenge, here we present a 12-color flow cytomet...

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Literature Corpus work
80a9061f-138c-5ba5-ae7f-74e048954b83
DOI
10.64898/2026.06.02.26354783
Open publication

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Cytoplasmic staining of T cell receptor components enables efficient assessment of lineage and clonality in surface CD3-negative T cell neoplasmsDOI 10.64898/2026.06.02.26354783
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