A <i>Plasmodium falciparum</i> Pangenome Resource to drive Structural Variant Discovery and assist Malaria Control

Abstract excerpt

Plasmodium falciparum , the deadliest causative agent of malaria, harbours extensive structural variation that underlies key biological processes including drug resistance and diagnostic evasion. Here, we present PfPan, a P. falciparum pangenome constructed from 13 geographically diverse high-quality reference genomes using Minigraph-Cactus, adding 4.7 Mb of sequence beyond the 3D7 linear reference. We identify o...

Topics

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• Aquaculture disease management and microbiota
• Evolution and Genetic Dynamics
• Genomics and Phylogenetic Studies
• Herpesvirus Infections and Treatments
• Malaria Research and Control
• Microbial infections and disease research
• Mosquito-borne diseases and control
• Vector-borne infectious diseases

Identifiers and source

Literature Corpus work

7e8a21e4-b54a-50ef-a64f-5dae90de89e8

DOI

10.64898/2026.05.19.726271