Article

In-silico phenotype-correlation analysis of Inherited variations in Autism Spectrum Disorder families identify complex interplay between genes encoding Sensory functions and Repetitive-Behaviours- a pilot study from India

2026-02-18

Abstract excerpt

<title>Abstract</title> <p> Autism Spectrum Disorder (ASD) is a neurodevelopmental condition with a strong genetic basis. Most genetic studies on ASD emphasize de novo mutations, while inherited rare variants remain understudied. We hypothesize that subtle, inherited ASD-related traits accumulate across generations and manifest as clinical ASD in offspring. To investigate this, we extracted inherited variations...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 7dfe5bff-9a5d-57ce-a61e-870f301aac06
DOI: 10.21203/rs.3.rs-8809718/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

In-silico phenotype-correlation analysis of Inherited variations in Autism Spectrum Disorder families identify complex interplay between genes encoding Sensory functions and Repetitive-Behaviours- a pilot study from IndiaDOI 10.21203/rs.3.rs-8809718/v1Read

Identification of Novel Gene variants for Autism Spectrum Disorder in an Indian Patient using Whole Exome SequencingSemantic proximity Read

Potentially damaging variants’ analysis in autism subgroups uncovers early brain-expressed gene modules relevant to autism pathophysiologySemantic proximity Read

Whole Exome Sequencing on a multiplex family of Indian origin identifies mutations at 17p11.2 in siblings with autism spectrum disorders: implications to understanding the pathophysiology from syndromic variants.Semantic proximity Read

Integrative Functional Genomic Analysis in Multiplex Autism Families from Kazakhstan.Semantic proximity Read

A systematic review of common genetic variation and biological pathways in autism spectrum disorder.Semantic proximity Read

Novel clinical, molecular and bioinformatics insights into the genetic background of autism.Semantic proximity Read

Contribution of Multiple Inherited Variants to Autism Spectrum Disorder (ASD) in a Family with 3 Affected Siblings.Semantic proximity Read

Genetic Spectrum of Autism Spectrum Disorder Associated Variants in the Indian Population: Insights from 1,029 IndiGenomesSemantic proximity Read

Elucidation of crucial metabolic pathways in the etiology of autism spectrum disorder through whole exome sequencing and chromosomal microarray.Semantic proximity Read

Identification of genetic variants and their causal association underlying autism spectrum disorderSemantic proximity Read

Genome Sequencing Identifies 13 Novel Candidate Risk Genes for Autism Spectrum Disorder in a Qatari Cohort.Semantic proximity Read

Functional relationships between recessive inherited genes and genes with de novo variants in autism spectrum disorder.Semantic proximity Read