Article

Rocbrutinib in Covalent BTK Inhibitor Exposed Relapsed or Refractory Mantle Cell Lymphoma: a Phase 2, Open-label, Multicenter, Single-arm Study

2026-05-12

Abstract excerpt

<title>Abstract</title> <p>Rocbrutinib is a fourth-generation Bruton’s tyrosine kinase (BTK) inhibitor with a unique dual covalent/non-covalent binding mechanism. Its efficacy and safety were evaluated in covalent BTK inhibitor-pretreated patients with mantle cell lymphoma in this phase 2 pivotal study. Patients received rocbrutinib until disease progression or unacceptable toxicities. The primary endpoint was ov...

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Literature Corpus work: 7d5329a6-a7db-50f5-97c2-33f1903a443c
DOI: 10.21203/rs.3.rs-9538133/v1

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