Nucleosomal association and altered interactome underlie the mechanism of cataract caused by the R54C mutation of αA-crystallin

Abstract excerpt

The small heat shock protein (sHSP), αA-crystallin, plays an important role in eye lens development. It has three distinct domains viz . the N-terminal domain, α-crystallin domain and the C-terminal extension. While the α-crystallin domain is conserved across the sHSP family, the N-terminal domain and the C-terminal extension are comparatively less conserved. Nevertheless, certain arginine residues in the N-termi...

Topics

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• Binding Sites
• Cataract
• Crystallins
• Lens, Crystalline
• Mutation
• Protein Conformation
• Proteostasis Deficiencies
• Stress, Physiological

Identifiers and source

Literature Corpus work

7b941306-07ab-5295-b8e7-299c6ae7dc4c

DOI

10.1101/2020.07.03.182295