Article

The 22q11 low copy repeats are characterized by unprecedented size and structure variability

2018-09-12

Abstract excerpt

<h4>Abstract:</h4> Low copy repeats (LCRs) are recognized as a significant source of genomic instability, driving genome variability and evolution. The chromosome 22 LCRs (LCR22s) are amongst the most complex regions in the genome and their structure remains unresolved. These LCR22s mediate non-allelic homologous recombination (NAHR) leading to the 22q11 deletion syndrome (22q11DS), causing the most frequent geno...

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Literature Corpus work: 7b888bc2-f15e-54b2-abf4-e1c78f149154
DOI: 10.1101/403873

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