Spatial Transcriptomics to define transcriptional patterns of zonation and structural components in the liver

Abstract excerpt

<h4>ABSTRACT</h4> Reconstruction of heterogeneity through single-cell transcriptional profiling has greatly advanced our understanding of the spatial liver transcriptome in recent years. However, global transcriptional differences across lobular units remain elusive in physical space. Here, we implement Spatial Transcriptomics to perform transcriptomic analysis across sectioned liver tissue. We confirm that the h...

Topics

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• Cytomegalovirus and herpesvirus research
• Gene Expression Profiling
• Molecular Biology Techniques and Applications
• Phenotype
• Single-cell and spatial transcriptomics
• Technology
• Transcriptome
• Transplantation: Methods and Outcomes

Identifiers and source

Literature Corpus work

7a935f64-35c9-5345-9eca-8f2bfa48dd12

DOI

10.1101/2021.01.11.426100