Article

Omicron mutations enhance infectivity and reduce antibody neutralization of SARS-CoV-2 virus-like particles

2021-12-21

Abstract excerpt

The Omicron SARS-CoV-2 virus contains extensive sequence changes relative to the earlier arising B.1, B.1.1 and Delta SARS-CoV-2 variants that have unknown effects on viral infectivity and response to existing vaccines. Using SARS-CoV-2 virus-like particles (SC2-VLPs), we examined mutations in all four structural proteins and found that Omicron showed 3-fold higher capsid assembly and cell entry relative to Delta,...

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Literature Corpus work: 7a32e305-4cd7-5735-aff6-f90e432a0bfb
DOI: 10.1101/2021.12.20.21268048

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