Article
Omicron mutations enhance infectivity and reduce antibody neutralization of SARS-CoV-2 virus-like particles.
Proceedings of the National Academy of Sciences of the United States of America - 2 Aug 2022
Syed Abdullah M, Ciling Alison, Taha Taha Y, Chen Irene P, Khalid Mir M, Sreekumar Bharath, Chen Pei-Yi, Kumar G Renuka, Suryawanshi Rahul, Silva Ines, Milbes Bilal, Kojima Noah, Hess Victoria, Shacreaw Maria, Lopez Lauren, Brobeck Matthew, Turner Fred, Spraggon Lee, Tabata Takako, Ott Melanie, Doudna Jennifer A
Abstract excerpt
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron variant contains extensive sequence changes relative to the earlier-arising B.1, B.1.1, and Delta SARS-CoV-2 variants that have unknown effects on viral infectivity and response to existing vaccines. Using SARS-CoV-2 virus-like particles (VLPs), we examined mutations in all four structural proteins and found that Omicron and Delta showed...
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