Chronic activation of Toll-like receptor 2 induces an ichthyotic skin phenotype

Abstract excerpt

Ichthyosis defines a group of chronic conditions that manifest phenotypically as a thick layer of fish-like scales in response to disorders of cornification and often affects the entire skin. While the gene mutations that lead to ichthyosis are well documented, the actual signalling mechanisms that lead to scaling are poorly characterised, however recent publications suggest that there are common mechanisms active...

Topics

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• Drug Development
• Ichthyosis
• Mutation
• Phenotype
• Proteomics
• Rats
• RNA, Small Interfering
• Toll-Like Receptor 2

Identifiers and source

Literature Corpus work

79e27505-c516-5ec6-b4d8-718ec410cf70

DOI

10.1101/2022.06.06.494922