Article

Human gut mobileome during antibiotic therapy. A trajectory-based approach to analysis of the metagenomic time-series datasets

2019-10-08

Abstract excerpt

<h4>Motivation</h4> Antibiotic resistance is widely recognized as a severe threat to current medical practice. Each antibiotic therapy drives the emergence and subsequent retention of antibiotics resistance genes within the human gut microbiome. However, the details on how the resistance spreads between bacteria within the human gut remain unknown, as does the role of horizontal gene transfer in this process, too...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 79a8535d-4203-5d34-a69a-ae1bdb4d2ac6
DOI: 10.1101/793737

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Human gut mobileome during antibiotic therapy. A trajectory-based approach to analysis of the metagenomic time-series datasetsDOI 10.1101/793737Read

Widespread transfer of mobile antibiotic resistance genes within individual gut microbiomes revealed through bacterial Hi-CSemantic proximity Read

Antibiotic Treatment Drives the Diversification of the Human Gut ResistomeSemantic proximity Read

Antibiotic Treatment Drives the Diversification of the Human Gut ResistomeSemantic proximity Read

Mobile genetic elements of the human gastrointestinal tractSemantic proximity Read

Prolonged Antibiotic Treatment Generates a Fluoroquinolone Resistant Gut Microbiome and Collateral Multi-Drug ResistanceSemantic proximity Read

Antibiotic perturbation of the human gut phageome preserves its individuality and promotes blooms of virulent phagesSemantic proximity Read

Metagenomic analysis of human, animal, and environmental samples identifies potential emerging pathogens, profiles antibiotic resistance genes, and reveals horizontal gene transfer dynamicsSemantic proximity Read

Antibiotics as both friends and foes of the human gut microbiome: The microbial community approachSemantic proximity Read

Widespread transfer of mobile antibiotic resistance genes within individual gut microbiomes revealed through bacterial Hi-CSemantic proximity Read

Transfer and Persistence of a Multi-Drug Resistance Plasmid in situ of the Infant Gut Microbiota in the Absence of Antibiotic TreatmentSemantic proximity Read

Plasmid dispersal and recombination across human gut microbiomes is neutral, but overpowered by inflammatory diseasesSemantic proximity Read

Distinct impact of antibiotics on the gut microbiome and resistome: a longitudinal multicenter cohort studySemantic proximity Read