Article

Natural Anti-NMDAR1 Autoantibodies Associate with Slowed Decline of Cognitive Functions in Alzheimer’s Diseases

2025-01-21

Abstract excerpt

Anti-NMDAR1 autoantibodies can bind NMDA receptors to suppress glutamate excitotoxicity in the brain. Low titers of blood circulating natural anti-NMDAR1 autoantibodies were reported in ∼10% of the general human population. We developed a new method to more accurately quantify these low titers of natural anti-NMDAR1 autoantibodies. After quantifying natural anti-NMDAR1 autoantibodies in the plasma of 324 age– and...

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Literature Corpus work: 792968c8-f0fb-5a53-adaa-9bcb824fdd3e
DOI: 10.1101/2025.01.16.25320688

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