Article

Interictal Epileptiform Discharges and Long-Term Neurodevelopmental Outcomes in Children with Early-Onset Epilepsy: A Systematic Review and Narrative Synthesis

2026-07-01

Abstract excerpt

<p>Background: Children with early-onset epilepsy (seizure onset ≤ 5 years) are at elevated risk of adverse neurodevelopmental outcomes, including cognitive impairment, intellectual disability, and autism spectrum features. Seizure burden alone provides limited prognostic information. Interictal epileptiform discharges (IEDs), spike or sharp-wave complexes occurring between clinical seizures on electroencephalogra...

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Literature Corpus work: 782d1442-b12e-52ba-8a34-857f98e4770f
DOI: 10.31234/osf.io/hkeaq_v1

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