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High False-Positive Rate of Syphilis Serological Screening in Male Blood Donors: A Molecular Validation Study

2026-01-26

Abstract excerpt

<h4>Background: </h4> Accurate serological screening is fundamental to transfusion safety. The VDRL test remains extensively used for syphilis screening despite documented limitations in sensitivity and specificity. Objectives This study validated VDRL results through PCR, determined true Treponema pallidum prevalence among VDRL-positive blood donors, established diagnostic accuracy of ELISA and rapid tests, and e...

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Literature Corpus work
75647ec5-0471-54be-ab24-cc5bae8c3f98
DOI
10.12688/f1000research.173728.1
Open publication

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High False-Positive Rate of Syphilis Serological Screening in Male Blood Donors: A Molecular Validation StudyDOI 10.12688/f1000research.173728.1
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