Article

An exploration of the genetics of the mutant <i>Huntingtin</i> (<i>mHtt</i>) gene in a cohort of patients with chorea from different tribes in 6 sub-Saharan African countries

2022-07-18

Abstract excerpt

<h4>Background</h4> Africans are underrepresented in Huntington’s disease research. A European ancestor was postulated to have introduced the mutant Huntingtin ( mHtt ) gene to the continent, however recent work has shown the existence of a unique Huntingtin haplotype in South-Africa specific to indigenous Africans. <h4>Objective</h4> We aimed to investigate the CAG repeats expansion in the Huntingtin ( Htt ) gene...

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Literature Corpus work: 74ff463f-73d0-597e-9c5a-252164337374
DOI: 10.1101/2022.07.13.22272435

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