Article

<p class="MDPI12titleori1" style="mso-line-height-alt: 14.0pt;"><span lang="EN-US" style="mso-bidi-font-size: 18.0pt; mso-ligatures: standardcontextual;">A Novel Variant of the <em>ACTRT1</em> Gene is Potentially Associated with Oligoasthenoteratozoospermia, Acrosome Detachment, and Fertilization Failure

2025-11-13

Abstract excerpt

<h4>Background: </h4> Male infertility is a common reproductive disorder, affecting about 7% of men in the general population. Despite its prevalence, the cause of infertility is often unknown. This case report presents the results of a comprehensive evaluation of a patient with severe oligoteratozoospermia and primary infertility. <h4>Methods:</h4> The patient underwent clinical, andrological, and genetic examina...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 746ec4fa-3bcb-50a3-9b83-c8a4125c6c2a
DOI: 10.20944/preprints202511.1008.v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

<p class="MDPI12titleori1" style="mso-line-height-alt: 14.0pt;"><span lang="EN-US" style="mso-bidi-font-size: 18.0pt; mso-ligatures: standardcontextual;">A Novel Variant of the <em>ACTRT1</em> Gene is Potentially Associated with Oligoasthenoteratozoospermia, Acrosome Detachment, and Fertilization FailureDOI 10.20944/preprints202511.1008.v1Read

Deletion of ACTRT1 is associated with male infertility as sperm acrosomal ultrastructural defects and fertilization failure in humanSemantic proximity Read

Pathogenic Variants in ACTRT1 Cause Acephalic Spermatozoa SyndromeSemantic proximity Read

Novel Variants in HFM1 Lead to Male Infertility Due to Non-obstructive AzoospermiaSemantic proximity Read

How exome sequencing improves the diagnostics and management of men with non‐syndromic infertilitySemantic proximity Read

A recessive ACTL7A founder variant leads to male infertility due to acrosome detachment in Pakistani PashtunsSemantic proximity Read

Genetic insights into non-obstructive azoospermia: Implications for diagnosis and TESE outcomesSemantic proximity Read

TENT5D disruption causes oligoasthenoteratozoospermia and male infertility.Semantic proximity Read

Bi-allelic Mutations in M1AP Are a Frequent Cause of Meiotic Arrest and Severely Impaired Spermatogenesis Leading to Male Infertility.Semantic proximity Read

Splicing Mutation in DNALI1 Causes Male Infertility with Severe Oligoasthenoteratozoospermia in Humans.Semantic proximity Read

A novel loss-of-function variant in PNLDC1 inducing oligo-astheno-teratozoospermia and male infertilitySemantic proximity Read

Novel variants in ACTL7A and PLCZ1 are associated with male infertility and total fertilization failureSemantic proximity Read

Novel bi-allelic variants in ACTL7A are associated with male infertility and total fertilization failureSemantic proximity Read