Article
MOLECULAR STRATIFICATION OF INTESTINAL AND DIFFUSE SUBTYPES OF GASTRIC ADENOCARCINOMA AND ITS PROGNOSTIC IMPACT
2025-09-17
Abstract excerpt
<h4>ABSTRACT</h4> Gastric adenocarcinoma is routinely classified by Lauren histology into Intestinal and Diffuse types; however, its prognostic use is limited by molecular heterogeneity within each subtype. We tested whether transcriptomic features refine risk beyond histology and whether biomarker signals generalize across populations. The premise is that when underlying programs diverge across tumors and cohort...
Topics
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- Cancer Mechanisms and Therapy
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Esophageal Cancer Research and Treatment
- Gastric Cancer Management and Outcomes
- Gastrointestinal Tumor Research and Treatment
- Genetic factors in colorectal cancer
- Helicobacter pylori-related gastroenterology studies
- Pancreatic and Hepatic Oncology Research
Identifiers and source
- Literature Corpus work
- 73cf10df-b777-5c5c-9adf-c2ef78f6c8c2
- DOI
- 10.1101/2025.09.14.676054