Article

Effects of Hypomethylating Agents on Gene Modulation in the Leukemic Microenvironment and Disease Trajectory in a Mouse Model of AML

2024-12-05

Abstract excerpt

<h4>ABSTRACT</h4> Hypomethylating agents (HMAs), such as decitabine and 5-azacytidine (AZA), are valuable treatment options for patients with acute myeloid leukemia that are ineligible for intensive chemotherapy. Despite providing significant extensions in survival when used alone or in combination, eventual relapse and resistance to HMAs are observed. The mechanisms leading to these outcomes are still not well d...

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Literature Corpus work: 71624719-f2fc-5b98-a63a-d1ee70cf53a6
DOI: 10.1101/2024.12.01.626276

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