Article

Lactoferrin binding to Sars-CoV-2 Spike glycoprotein protects host from infection, inflammation and iron dysregulation.

2022-05-17

Abstract excerpt

<title>Abstract</title> <p>The anti-SARS-Cov-2 activity of the iron-binding protein Lactoferrrin has been investigated in epithelial and macrophagic cell models using a Pseudovirus decorated with the SARS-CoV-2 Spike glycoprotein. The human and, even more, the nutraceutically available bovine Lactoferrin inhibit pseudoviral infection in all cellular models tested. The bovine protein efficiently counteracts the de...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 7008063f-16b9-5cbc-b0ef-c9ddff4889d9
DOI: 10.21203/rs.3.rs-1605740/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Lactoferrin binding to Sars-CoV-2 Spike glycoprotein protects host from infection, inflammation and iron dysregulation.DOI 10.21203/rs.3.rs-1605740/v1Read

COVID-19 and iron dysregulation: distant sequence similarity between hepcidin and the novel coronavirus spike glycoproteinSemantic proximity Read

The Biology of Lactoferrin, an Iron-Binding Protein That Can Help Defend Against Viruses and BacteriaSemantic proximity Read

Inhibition of SAR S-CoV-2 infection and replication by lactoferrin, MUC1 and α-lactalbumin identified in human breastmilkSemantic proximity Read

SARS-CoV-2 proteins bind heme and hemoglobinSemantic proximity Read

Targeting bacterial transferrin and lactoferrin receptors for vaccinesSemantic proximity Read

The Multifaceted Functions of Lactoferrin in Antimicrobial Defense and InflammationSemantic proximity Read

The spike protein of SARS-CoV-2 induces heme oxygenase-1: Pathophysiologic implicationsSemantic proximity Read

A possible way to relate the effects of SARS-CoV-2 induced changes in transferrin to severe COVID-19 associated diseasesSemantic proximity Read

TIPE2 suppresses ferroptosis and pro-inflammatory polarization in macrophages triggered by SARS-CoV-2 spike proteinSemantic proximity Read

Lactoferrin: structure, function and applicationsSemantic proximity Read

Bovine lactoferrin suppresses the cathepsin-dependent pathway of SARS-CoV-2 entry in vitroSemantic proximity Read

Bacterial Receptors for Host Transferrin and Lactoferrin: Molecular Mechanisms and Role in Host–Microbe InteractionsSemantic proximity Read