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The mitochondrial DNA constitution shaping T cell immunity in patients with rectal cancer at high risk of metastatic progression

2021-06-13

Abstract excerpt

A significant percentage of colorectal cancer patients proceeds to metastatic disease. We hypothesised that mitochondrial DNA (mtDNA) polymorphisms, generated by the high mtDNA mutation rate of energy-demanding clonal immune cell expansions and assessable in peripheral blood, reflect how efficiently systemic immunity impedes metastasis. We studied 44 rectal cancer patients from a population-based prospective bioma...

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Literature Corpus work
6f057a5a-2cbe-55c1-a8bc-896e0cb5e8a6
DOI
10.22541/au.162361415.51409527/v1
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The mitochondrial DNA constitution shaping T cell immunity in patients with rectal cancer at high risk of metastatic progressionDOI 10.22541/au.162361415.51409527/v1
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