Article

ZSCAN18 Promoter is Hypermethylated and Its Restored Expression Inhibits Proliferation in Gastric Cancer

2021-12-16

Abstract excerpt

<title>Abstract</title> <p><bold>Background:</bold> Zinc finger and scan domain containing 18 (ZSCAN18) belongs to the zinc finger transcription factor superfamily, which consists of hundreds of members that play critical roles in all steps of tumorigenesis. Although hypermethylation of the ZSCAN18 promoter and its consequent deficiency in a variety of malignancies have been reported recently, its functions and m...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 6ee2fca6-4077-528c-98b2-75c2018e96d2
DOI: 10.21203/rs.3.rs-1120023/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

ZSCAN18 Promoter is Hypermethylated and Its Restored Expression Inhibits Proliferation in Gastric CancerDOI 10.21203/rs.3.rs-1120023/v1Read

Inactivation of ZSCAN18 by promoter hypermethylation drives the proliferation via attenuating TP53INP2-mediated autophagy in gastric cancer cellsSemantic proximity Read

Identification of a novel hypermethylation marker, ZSCAN18, and construction of a diagnostic model in cervical cancerSemantic proximity Read

A Novel Tumor Suppressor Gene, TMEM171, Inhibits the Development of Gastric Cancer by Dephosphorylating IKBα and Inactivating the NF-kB Signaling PathwaySemantic proximity Read

ZNF114 Promotes Gastric Cancer Progression by Inducing Epithelial–Mesenchymal Transition and Shaping an Immunosuppressive Tumor MicroenvironmentSemantic proximity Read

ZNF750 is a lineage-specific tumour suppressor in squamous cell carcinoma.Semantic proximity Read

Chromatin Accessibility Regulates Gene Expression and Correlates With Tumor-Infiltrating Immune Cells in Gastric AdenocarcinomaSemantic proximity Read

RN181 is a tumour suppressor in gastric cancer by regulation of the ERK/MAPK–cyclin D1/CDK4 pathwaySemantic proximity Read

Integrated exome and transcriptome sequencing reveals ZAK isoform usage in gastric cancer.Semantic proximity Read

HNF1A-Induced lncRNA HCG18 Facilitates Gastric Cancer Progression by Upregulating DNAJB12 via miR-152-3pSemantic proximity Read

Hypermethylation of Sox17 gene is useful as a molecular diagnostic application in early gastric cancerSemantic proximity Read

Silencing SHMT2 Inhibits the Progression of Oral Squamous Cell Carcinoma Through Cell Cycle RegulationSemantic proximity Read

<i>MAL</i> and <i>TMEM220</i> are novel DNA methylation markers in human gastric cancerSemantic proximity Read