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Clinical Validation of a Novel Quantitative Assay for the Detection of MGMT Methylation in Glioblastoma Patients

2020-08-04

Abstract excerpt

The promoter hypermethylation of the methylguanine-DNA methyltransferase (MGMT) gene is a frequently used biomarker in daily clinical practice as it is associated with a favorable prognosis in glioblastoma patients treated with temozolamide. In this study we carried out a clinical validation of a quantitative assay for MGMT methylation detection by comparing a novel MSP custom assay using double-probe characterist...

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Literature Corpus work
6e857a7c-e030-591f-8cb4-40c37275b3ad
DOI
10.20944/preprints202008.0096.v1
Open publication

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