Back to search

Article

Network Pharmacology Prediction and Experimental Validation of Apocynin Against Colon Adenocarcinoma: Identification of CCND1 and CXCL8 as Key Targets

2026-06-08

Abstract excerpt

<title>Abstract</title> <p>Background Colon adenocarcinoma (COAD) remains a leading cause of cancer-related mortality, necessitating novel therapeutic strategies. Apocynin, a natural NADPH oxidase inhibitor, exhibits anti-tumor potential, yet its precise mechanisms against COAD remain poorly characterized. Methods An integrative approach combining, bioinformatics, molecular docking, and in vitro experimental va...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
6d7454db-acf6-5187-b68d-56f6d43f6b52
DOI
10.21203/rs.3.rs-9841007/v1
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Network Pharmacology Prediction and Experimental Validation of Apocynin Against Colon Adenocarcinoma: Identification of CCND1 and CXCL8 as Key TargetsDOI 10.21203/rs.3.rs-9841007/v1
Identification and verification of 3 key genes associated with survival and prognosis of patients with colon adenocarcinoma via integrated bioinformatics analysisSemantic proximity
Identification of Key Biomarkers Associated with Survival and Prognosis in Colon AdenocarcinomaSemantic proximity
Assessing the prognostic and therapeutic value of cuproptosis-related genes in colon adenocarcinoma patientsSemantic proximity
Identification of Prognostic Biomarker Signatures and Candidate Drugs in Colorectal Cancer: Insights from Systems Biology AnalysisSemantic proximity
Integrated Network Pharmacology and Molecular Docking Reveal Therapeutic Potential of Moringa oleifera Glycosides, Targeting Key Regulatory Genes in Colorectal CancerSemantic proximity
Network pharmacology and molecular docking study on the mechanism of colorectal cancer treatment using Xiao-Chai-Hu-TangSemantic proximity
HTR1D, TIMP1, SERPINE1, MMP3 and CNR2 affect the survival of patients with colon adenocarcinomaSemantic proximity
Identification of Prognostic Biomarker Signatures and Candidate Drugs in Colorectal Cancer: Insights from Systems Biology AnalysisSemantic proximity
Network Pharmacology Study and Molecular Docking on the Mechanism of Treatment of Colorectal Cancer by Xiao-Chai-Hu-TangSemantic proximity
Identification of a glycolysis- and lactate-related gene signature for predicting prognosis, immune microenvironment, and drug candidates in colon adenocarcinomaSemantic proximity
Systems Biology Approach to Gene Network Analysis Identifies Therapeutic and Diagnostic Targets in Colorectal CancerSemantic proximity
Astragalus mongholicus Bunge and Curcuma aromatica Salisb. inhibits liver metastasis of colon cancer by regulating EMT via the CXCL8/CXCR2 axis and PI3K/AKT/mTOR signaling pathwaySemantic proximity
Select a neighboring publication to make it the new centre.