Article

RNA-Dependent RNA Polymerase and Spike Protein Mutant Variants of SARS-CoV-2 Predominate in Severely Affected COVID-19 Patients

2020-07-12

Abstract excerpt

The severity of coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), greatly varies from patient to patient. In the present study, we explored and compared mutation profiles of SARS-CoV-2 isolated from mildly affected and severely affected COVID-19 patients in order to explore any relationship between mutation profile and disease severity. Genomic sequenc...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 6d072755-b2f1-5c2e-94bb-25d2d64effe5
DOI: 10.20944/preprints202007.0251.v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

RNA-Dependent RNA Polymerase and Spike Protein Mutant Variants of SARS-CoV-2 Predominate in Severely Affected COVID-19 PatientsDOI 10.20944/preprints202007.0251.v1Read

Spike protein D614G and RdRp P323L: the SARS-CoV-2 mutations associated with severity of COVID-19Semantic proximity Read

SARS-CoV-2 outbreak: role of viral proteins and genomic diversity in virus infection and COVID-19 progressionSemantic proximity Read

Severe Acute Respiratory Syndrome Coronavirus-2 genome sequence variations relate to morbidity and mortality in Coronavirus Disease-19Semantic proximity Read

The Impact of SARS-CoV-2 Multiple Spike Protein Mutations on COVID-19 OutcomesSemantic proximity Read

Emerging SARS-CoV-2 Genetic Variations and Mutations in the COVID-19 genomic sequence: A Systematic and Meta-analysis reviewSemantic proximity Read

Mutations in SARS-CoV-2 spike protein and RNA polymerase complex are associated with COVID-19 mortality riskSemantic proximity Read

Mutations in the genome of severe acute respiratory syndrome coronavirus 2: implications for COVID-19 severity and progression.Semantic proximity Read

Mutations in SARS-CoV-2; Consequences in structure, function, and pathogenicity of the virus.Semantic proximity Read

Some common deleterious mutations are shared in SARS-CoV-2 genomes from deceased COVID-19 patients across continents.Semantic proximity Read

Two mutations in the SARS-CoV-2 spike protein and RNA polymerase complex are associated with COVID-19 mortality riskSemantic proximity Read

A multi-population-based genomic analysis uncovers unique haplotype variants and crucial mutant genes in SARS-CoV-2Semantic proximity Read

Genomic Variations in the Structural Proteins of SARS-CoV-2 and Their Deleterious Impact on Pathogenesis: A Comparative Genomics ApproachSemantic proximity Read