Article

DNA-Based Deep Learning and Association Studies for Drug Response Prediction in Leiomyosarcoma

2025-10-24

Abstract excerpt

Leiomyosarcoma (LMS) is a rare and aggressive soft tissue sarcoma with limited treatment options and poor prognosis. Standard therapies, including doxorubicin, gemcitabine, trabectedin, and pazopanib, demonstrate variable efficacy across patients, underscoring the need for predictive biomarkers and computational models to inform personalized therapy. We developed a deep learning framework using DNA mutation and ex...

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Literature Corpus work: 6cd99a2f-0e68-5b87-916b-9a1a426439b8
DOI: 10.1101/2025.10.22.25338578

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