Article

Senataxin loss induces cGAS–STING-mediated mitochondrial dysfunction

2026-06-27

Abstract excerpt

Ataxia with oculomotor apraxia type 2 (AOA2) is a rare neurodegenerative disease caused by loss-of-function mutations in Senataxin, which encodes an RNA:DNA helicase. Many studies on Senataxin loss focus on its putative roles in regulating transcription and RNA transcript localization. However, several phenotypes remain underexplored, including metabolic dysregulation associated with ataxias. Using Senataxin-defi...

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Literature Corpus work: 6b03751b-80e4-5318-a2d6-7cfd1eef741f
DOI: 10.64898/2026.06.26.734838

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