Article

Small-molecule cocktails induce the differentiation of human adipose-derived mesenchymal stem cells into hepatocyte-like cells

2021-07-19

Abstract excerpt

At present, liver transplantation and hepatocyte therapy are common methods for the treatment of end-stage liver diseases, but they are restricted due to the shortage of liver donors and the safety and effectiveness of hepatocyte sources. Human adipose-derived mesenchymal stem cells (HAD-MSCs) have been applied to efficiently and stably induce phenotypic and functional liver cells or tissues in vitro due to their...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 6a227392-e96c-5fcb-bc79-83194c1593d5
DOI: 10.1101/2021.07.19.452852

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Small-molecule cocktails induce the differentiation of human adipose-derived mesenchymal stem cells into hepatocyte-like cellsDOI 10.1101/2021.07.19.452852Read

Generation of liver organoids from human induced pluripotent stem cells as liver fibrosis and steatosis modelsSemantic proximity Read

Different approaches for transformation of mesenchymal stem cells into hepatocyte-like cellsSemantic proximity Read

Hepatocyte-like cells derived from human induced pluripotent stem cells using small molecules: implications of a transcriptomic studySemantic proximity Read

In Vitro Differentiation of Embryonic and Adult Stem Cells into Hepatocytes: State of the ArtSemantic proximity Read

Efficiently generate functional hepatic cells from human pluripotent stem cells by complete small-molecule strategySemantic proximity Read

Cell therapy for liver diseases: current medicine and future promises.Semantic proximity Read

The Use of Induced Pluripotent Stem Cells for the Study and Treatment of Liver DiseasesSemantic proximity Read

Pluripotent Stem Cell-Derived Hepatocyte-like Cells: Induction Methods and ApplicationsSemantic proximity Read

Exosomes Derived from Human Adipose Mesenchymal Stem Cells Ameliorate Hepatic Fibrosis by Regulating Choline Metabolism and PI3K/Akt/mTOR PathwaySemantic proximity Read

Adipose tissue-derived mesenchymal stem cells differentiated into hepatocyte-like cells in vivo and in vitro.Semantic proximity Read

Liver organoids: established tools for disease modeling and drug developmentSemantic proximity Read

Stem Cell Therapies for Treatment of Liver DiseaseSemantic proximity Read