Article

Incorporating genome-based phylogeny and functional similarity into diversity assessments helps to resolve a global collection of human gut metagenomes

2020-07-17

Abstract excerpt

Tree-based diversity measures incorporate phylogenetic or functional relatedness into comparisons of microbial communities. This can improve the identification of explanatory factors compared to tree-agnostic diversity measures. However, applying tree-based diversity measures to metagenome data is more challenging than for single-locus sequencing ( e . g ., 16S rRNA gene). The Genome Taxonomy Database (GTDB) pro...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 6a103667-d695-5f10-8ecc-c609834e6f67
DOI: 10.1101/2020.07.16.207845

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Incorporating genome-based phylogeny and functional similarity into diversity assessments helps to resolve a global collection of human gut metagenomesDOI 10.1101/2020.07.16.207845Read

A Metagenomic Meta-Analysis Reveals Functional Signatures of Health and Disease in the Human Gut MicrobiomeSemantic proximity Read

A Novel Index for Predicting Health Status Using Species-level Gut Microbiome ProfilingSemantic proximity Read

Exploring the functional composition of the human microbiome using a hand-curated microbial trait database.Semantic proximity Read

A predictive index for health status using species-level gut microbiome profilingSemantic proximity Read

Strains, functions and dynamics in the expanded Human Microbiome ProjectSemantic proximity Read

gutMEGA: a database of the human gut MEtaGenome Atlas.Semantic proximity Read

A Tree of Human Gut Bacterial Species and its Applications to Metagenomics and Metaproteomics Data AnalysisSemantic proximity Read

Proteobacteria drive significant functional variability in the human gut microbiomeSemantic proximity Read

Metagenome-assembled genomes from a population-based cohort uncover novel gut species and within-species diversity, revealing prevalent disease associationsSemantic proximity Read

Towards a Health-Associated Core Keystone (HACK) index for the human gut microbiomeSemantic proximity Read

Exploring the universal healthy human gut microbiota around the WorldSemantic proximity Read

Metagenome-assembled genomes from a population-based cohort uncover novel gut species and within-species diversity, revealing prevalent disease associations.Semantic proximity Read