Article

Automated Multiplex Plasma Proteomics for Quality Assessment and Clinical Triage: A Proof-of-Concept in Indeterminate Thyroid Nodules

2026-01-16

Abstract excerpt

Fine-needle aspiration biopsy of thyroid nodules frequently yields indeterminate results, leading to unnecessary diagnostic surgeries. We evaluated a targeted plasma proteomics approach to differentiate benign follicular thyroid adenoma (FTA) from malignant papillary thyroid carcinoma (PTC). Using LC-MRM mass spectrometry with stable isotope-labeled standards (SIS), we quantified a multiplex protein panel in plasm...

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Literature Corpus work: 69e9c0e8-c2ad-5ae6-bea4-7f9344dd2c48
DOI: 10.64898/2026.01.15.699717

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