Article
A targeted proteomics assay for the preoperative diagnosis of thyroid nodules.
Cell reports. Medicine - 17 Mar 2026
Cai Xue, Sun Yaoting, Luo Dingcun, Zhang Hao, Wei Wenjun, Zhang Yifeng, Ge Weigang, Liu Jing, Ruan Guan, Li Lu, Tan Lingling, Xu Luang, Xu Dong, Guan Haixia, Zhu Jiang, Chen Wanyuan, Zhang Qiushi, Si Huijuan, Qiu Juntao, Xue Zhangzhi, Gui Zhiqiang, Zheng Haitao, Wu Gaosong, Wang Jianhua, Xie Lei, Chen Guang, Wu Guoyang, Liang Lei, Chen Chuang, He Xianghui, Shen Meiping, Wang Jianbiao, Ge Minghua, Zhang Deguang, Zhou Liang, Wu Yijun, Shi Hui, Wu Fan, Wang Zhihong, Han Hong, Yao Jing, Liu Zhiyan, Xing Mingzhao, Kakudo Kennichi, Gao Yibo, Tian Wen, Xu Huixiong, Zhu Yi, Wang Yu, Guo Tiannan
Abstract excerpt
Accurate preoperative diagnosis of thyroid nodules via fine-needle aspiration (FNA) biopsy remains challenging, particularly in cases with indeterminate cytology. This prospective, noninterventional, blinded, multicenter study establishes ThyroProt, a diagnostic classifier that integrates targeted mass-spectrometry-based quantification of a 3-protein signature with BRAF V600E mutation status, age, and gender....
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