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Article

NECTIN-4 PET FOR OPTIMIZING ENFORTUMAB VEDOTIN DOSE-RESPONSE IN UROTHELIAL CARCINOMA

2024-12-25

Abstract excerpt

<h4>ABSTRACT</h4> The optimization of dosing strategies is critical for maximizing efficacy and minimizing toxicity in drug development, particularly for drugs with narrow therapeutic windows such as antibody-drug conjugates (ADCs). This study demonstrates the utility of Nectin-4-targeted positron emission tomography (PET) imaging using [ 68 Ga]AJ647 as a non-invasive tool for real-time assessment of target enga...

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Literature Corpus work
67a78b8f-c392-53a9-96ab-5212083e9738
DOI
10.1101/2024.12.25.630315
Open publication

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