Back to search

Article

Targeting melanosome pH is an effective method for the treatment of oculocutaneous albinism

2026-05-28

Abstract excerpt

Oculocutaneous albinism (OCA) is a genetic condition associated with impaired visual acuity and increased skin cancer risk. When OCA is due to defects in melanosome ion transport, abnormally acidic conditions in the melanosome lumen inhibit tyrosinase, the critical pigment synthetic enzyme. Hence, a therapeutic approach that optimizes melanosome pH to increase pigment production presents a potential treatment for...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
6787122d-eefb-597d-ac88-050cb1cc302f
DOI
10.64898/2026.05.25.727673
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Targeting melanosome pH is an effective method for the treatment of oculocutaneous albinismDOI 10.64898/2026.05.25.727673
Ampyrone (4-Aminoantipyrine) is a Direct Agonist of Human Tyrosinase and Potential Therapeutic for Oculocutaneous Albinism and Disorders of HypopigmentationSemantic proximity
The tyrosinase gene and oculocutaneous albinism type 1 (OCA1): A model for understanding the molecular biology of melanin formation.Semantic proximity
DNA variations in oculocutaneous albinism: an updated mutation list and current outstanding issues in molecular diagnostics.Semantic proximity
TYR mutation in a Chinese population with oculocutaneous albinism: Molecular characteristics and ophthalmic manifestations.Semantic proximity
An intracellular anion channel critical for pigmentation.Semantic proximity
Molecular Characterization of Oculocutaneous Albinism in Consanguineous Pakistani Families: Unraveling Disease-Causing Pathogenic Variants in OCA2 and TYR Genes for Precision Diagnosis.Semantic proximity
Dopachrome tautomerase variants in patients with oculocutaneous albinism.Semantic proximity
Dopachrome tautomerase variants in patients with oculocutaneous albinismSemantic proximity
Identification of a missense mutation in the tyrosinase gene in a Chinese family with oculocutaneous albinism type 1.Semantic proximity
Unveiling genetics of non-syndromic albinism using whole exome sequencing: A comprehensive study of TYR, TYRP1, OCA2 and MC1R genes in 17 families.Semantic proximity
A genome-wide genetic screen uncovers determinants of human pigmentationSemantic proximity
Oculocutaneous albinismSemantic proximity
Select a neighboring publication to make it the new centre.