Article

IL-17A-mediated alterations in gut microbiota composition, particularly changes in Prevotella abundance, impact Treg function in CNS Autoimmunity

2022-04-22

Abstract excerpt

A disrupted equilibrium among gut microbiota, IL-17A-producing CD4 T-cells (Th17), and regulatory CD4 T-cells (Treg) have been linked with the pathobiology of multiple sclerosis (MS). While gut microbiota can regulate both Treg and Th17 cells, the impact of IL-17A on this gut-immune connection remains unclear. Utilizing HLA-DR3 transgenic mouse model of MS, we show that IL-17A deficiency (HLA-DR3.IL17A -/- ) resu...

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Identifiers and source

Literature Corpus work: 67762192-9dcc-5b08-932f-0f6f1a6adf2e
DOI: 10.1101/2022.04.22.489206

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