Article

Atsttrin Regulates Osteoblastogenesis and Osteoclastogenesis through TNFR Pathway

2023-02-20

Abstract excerpt

<title>Abstract</title> <p>Osteoporosis is a systemic metabolic bone disease. Osteoporosis is believed to be a systemic inflammatory condition in which inflammatory cytokines play an important role. Among these molecules, tumor necrosis factor-α (TNF-α) plays an important role in the initiation and development of osteoporosis. Atsttrin is an engineered protein derived from the growth factor, progranulin (PGRN). I...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 6743aa0c-12e9-52d2-ab88-f61e8b86e8cc
DOI: 10.21203/rs.3.rs-2565180/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Atsttrin Regulates Osteoblastogenesis and Osteoclastogenesis through TNFR PathwayDOI 10.21203/rs.3.rs-2565180/v1Read

Progranulin-Derived Atsttrin Directly Binds to TNFRSF25 (DR3) and Inhibits TNF-Like Ligand 1A (TL1A) ActivitySemantic proximity Read

Hyperoside Suppresses Osteoclasts Differentiation and Function through Down-Regulating TRAF6/p38 MAPK Signaling PathwaySemantic proximity Read

Wnt/β-catenin signaling pathway: proteins' roles in osteoporosis and cancer diseases and the regulatory effects of natural compounds on osteoporosisSemantic proximity Read

Si-Wu-Tang Promotes Cell Proliferation and Osteogenic Gene Expression during Osteoblastogenesis Yet Dampens the Formation of OsteoclastSemantic proximity Read

The promotion of bone healing by progranulin, a downstream molecule of BMP-2, through interacting with TNF/TNFR signalingSemantic proximity Read

Alpinetin Inhibits RANKL-Induced Osteoclastogenesis and Ovariectomy-Induced Bone Loss by Modulating NFATc1 Transcription and Lysosomal FunctionSemantic proximity Read

Knockdown of SERPINB2 enhances the osteogenic differentiation of human bone marrow mesenchymal stem cells via activation of the Wnt/β-catenin signalling pathwaySemantic proximity Read

Exploring the In Vitro Effects of Zingerone on Differentiation and Signalling Pathways in Bone Cell LinesSemantic proximity Read

Osteoblast Role in Rheumatic DiseasesSemantic proximity Read

Ataluren Prevented Bone Loss Induced by Ovariectomy and Aging in Mice Through the BMP-SMAD Signaling PathwaySemantic proximity Read

Osteoporosis - a current view of pharmacological prevention and treatment.Semantic proximity Read

Regulatory roles and molecular signaling of TNF family members in osteoclastsSemantic proximity Read