Article

Validation and testing of an in vitro model to study medical treatments for anterior urethral stricture disease: assessing the potential efficacy of phosphodiesterase-4 (PDE4) inhibition and testosterone

2026-05-17

Abstract excerpt

<h4>Objective</h4> To 1) determine the expression and distribution of all PDE4 isozymes (A-D) along the length of the anterior urethra, 2) culture fibroblasts and epithelial cells from healthy and strictured urethras, 3) investigate an in vitro model of anterior urethral stricture disease (aUSD), and 4) assess the therapeutic potential of phosphodiesterase-4 (PDE4) inhibitors and testosterone compared to paclita...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 66dfc968-a6c2-5063-95f5-d9763523f927
DOI: 10.64898/2026.05.13.724950

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Validation and testing of an in vitro model to study medical treatments for anterior urethral stricture disease: assessing the potential efficacy of phosphodiesterase-4 (PDE4) inhibition and testosteroneDOI 10.64898/2026.05.13.724950Read

Diagnosis and Treatment of Anterior Urethral Strictures in China: An Internet-Based SurveySemantic proximity Read

Deep Phenotyping the Anterior Urethral Stricture: Characterizing the Relationship Between Inflammation, Fibrosis, Patient History, and Disease Pathophysiology.Semantic proximity Read

Elucidation of Inflammatory-Fibrotic Microenvironment in Human Urethral Stricture DiseaseSemantic proximity Read

Phosphodiesterase Type 5 Inhibitors in Male Reproduction: Molecular Mechanisms and Clinical Implications for Fertility ManagementSemantic proximity Read

Current and emerging drugs for interstitial cystitis/bladder pain syndrome (IC/BPS).Semantic proximity Read

PDE4DIP in health and diseasesSemantic proximity Read

Management of High Urogenital Sinus in Adults: A Scoping ReviewSemantic proximity Read

Peyronie's disease: the epidemiology, aetiology and clinical evaluation of deformity.Semantic proximity Read

Once upon a Testis: The Tale of Cyclic Nucleotide Phosphodiesterase in Testicular CancersSemantic proximity Read

Overactive bladder phenotypes: development and preliminary data.Semantic proximity Read

Contemporary diagnosis of lower urinary tract dysfunction.Semantic proximity Read

Molecular Subtypes of Balanopreputial and Urethral Male Genital Lichen Sclerosus: Distinct Transcriptomic and Clinicopathological ProfilesSemantic proximity Read