Article

AOPGraphExplorer 2.0: An Interactive Graph-Based Platform for Multi-Domain Mechanistic Annotation and Exploration of Adverse Outcome Pathways

2026-03-02

Abstract excerpt

The Adverse Outcome Pathway (AOP) framework is a cornerstone of modern mechanistic toxicology, providing a structured representation of causal biological events linking molecular initiating events to adverse health outcomes. However, the practical exploration and interpretation of AOPs remain challenging due to the fragmentation of mechanistic knowledge across heterogeneous biological databases and the limited ava...

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Literature Corpus work: 653cb6b1-26b3-5c03-b81a-04b4266df8d0
DOI: 10.64898/2026.02.27.708648

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