Back to search

Article

Calcitriol Downregulates ACE1/ACE2, Renin and TMPRSS2 Gene Expression in the Human Placenta

2023-11-07

Abstract excerpt

Angiotensin-converting enzyme (ACE)1, ACE2, and renin are components of the renin-angiotensin system (RAS), which regulates blood pressure. ACE2 also serves as a receptor for SARS-CoV-2 and together with the transmembrane serine protease 2 (TMPRSS-2), mediates viral cell-endocytosis. As the placenta expresses all these factors, it acts as a target for SARS-CoV-2 and also as a source of blood pressure modulators. A...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
64e6e310-c3fc-5cc6-a1ba-e5b697a1d78c
DOI
10.20944/preprints202311.0402.v1
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Calcitriol Downregulates ACE1/ACE2, Renin and TMPRSS2 Gene Expression in the Human PlacentaDOI 10.20944/preprints202311.0402.v1
Role of ACE2 in pregnancy and potential implications for COVID-19 susceptibilitySemantic proximity
COVID-19 infection: ACE2, pregnancy and preeclampsiaSemantic proximity
A placental model of SARS-CoV-2 infection reveals ACE2-dependent susceptibility and differentiation impairment in syncytiotrophoblastsSemantic proximity
COVID-19 susceptibility in pregnancy: Immune/inflammatory considerations, the role of placental ACE-2 and research considerationsSemantic proximity
Can Similarities between the Pathogenesis of Preeclampsia and COVID-19 Increase the Understanding of COVID-19?Semantic proximity
Consistent localization of SARS-CoV-2 spike glycoprotein and ACE2 over TMPRSS2 predominance in placental villi of 15 COVID-19 positive maternal-fetal dyadsSemantic proximity
SARS-CoV-2 ACE-receptor detection in the placenta throughout pregnancySemantic proximity
An iTSC-derived placental model of SARS-CoV-2 infection reveals ACE2-dependent susceptibility in syncytiotrophoblastsSemantic proximity
COVID-19 and Vertical Transmission: Assessing the Expression of ACE2 / TMPRSS2 in the Human Fetus and Placenta to Assess the Risk of SARS-CoV-2 InfectionSemantic proximity
Association of ACE2 Gene Variants with Adverse Perinatal Outcomes in COVID-19 Infected Pregnant Women in Kazakhstan.Semantic proximity
COVID-19 and vertical transmission: assessing the expression of ACE2 / TMPRSS2 in the human fetus and placenta to assess the risk of SARS-CoV-2 infection.Semantic proximity
Protein expression of angiotensin‐converting enzyme 2, a SARS‐CoV ‐2‐specific receptor, in fetal and placental tissues throughout gestation: new insight for perinatal counselingSemantic proximity
Select a neighboring publication to make it the new centre.