Article

Use of AXL-specific CAR T cells to treat non-small-cell lung cancer

2021-02-16

Abstract excerpt

<title>Abstract</title> <p>The application of Chimeric antigen receptor (CAR) T cells in solid tumors is hindered by lack of tumor specific targets and inefficient T cell infiltration in tumor. It has been postulated that AXL may be an ideal immunotherapy target for non-small-cell lung cancer (NSCLC). Here, we screened 208 non-tumor samples from 22 types of human organs or tissues and 90 tumor samples from NSCLC...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 649685d2-6a0f-5918-9808-2b83eba79d2a
DOI: 10.21203/rs.3.rs-244810/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Use of AXL-specific CAR T cells to treat non-small-cell lung cancerDOI 10.21203/rs.3.rs-244810/v1Read

Cellular Therapy for Lung Cancer: Focusing on Chimeric Antigen Receptor T (CAR T) Cells and Tumor-Infiltrating Lymphocyte (TIL) TherapySemantic proximity Read

[Research Progress of Immunotherapy for Non-small Cell Lung Cancer with Drive Gene Mutation].Semantic proximity Read

AXL up-regulates PD-L1 inducing gefitinib resistance in EGFR mutated NSCLCSemantic proximity Read

Natural killer cell‑based immunotherapy for lung cancer: Challenges and perspectives (Review)Semantic proximity Read

Ligand-based, piggyBac-engineered CAR-T cells targeting EGFR are safe and effective against non-small cell lung cancersSemantic proximity Read

The evolution of T-cell receptor repertoire in different stages of non-small cell lung cancerSemantic proximity Read

High levels of AXL expression in untreated EGFR-mutated non-small cell lung cancer negatively impacts the use of osimertinib.Semantic proximity Read

[Primary Application of Radiofrequency Ablation after Locally Progression of EGFR-TKIs in Non-small Cell Lung Cancer].Semantic proximity Read

An innovative treatment for lung cancer using gene-engineered human-induced pluripotent stem cell- derived natural killer cellsSemantic proximity Read

Image-guided thermal ablation for patients with epidermal growth factor receptor-mutant nonsmall cell lung cancer.Semantic proximity Read

BTLA Expression in Stage I–III Non–Small-Cell Lung Cancer and Its Correlation with PD-1/PD-L1 and Clinical OutcomesSemantic proximity Read

Clinical, Pathological, and Molecular Features of Lung Adenocarcinomas with AXL Expression.Semantic proximity Read