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Operationalizing the Biological Burden Index in Autism: A Critical Integrative Framework for Multidomain Biological Measurement, Precision Stratification, and Translational Research

2026-07-15

Abstract excerpt

<h4>Background: </h4> Autism spectrum disorder (ASD) is characterized by substantial biological and clinical heterogeneity that cannot be adequately explained by isolated biomarkers or single-system models. The Biological Burden Index (BBI) has been proposed as a hypothesis-generating multidimensional framework to organize convergent biological dysregulations that may contribute to interindividual variability in a...

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Literature Corpus work
6419fa13-09df-5af1-8201-c66a0e28b883
DOI
10.20944/preprints202607.1153.v1
Open publication

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