Multi-omics dissection of lifespan neuroanatomical subtypes in autism

Abstract excerpt

<title>Abstract</title> <p>Unraveling the heterogeneity of autism spectrum disorder (ASD) remains a major challenge yet crucial for elucidating the etiological underpinnings. Leveraging large-scale MRI data from 60,234 healthy participants and 3,117 individuals with ASD, we established lifespan brain charts of cortical thickness (CT) and surface area (SA) and derived personalized centile scores indexing deviation...

Topics

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• Adolescent
• Age Factors
• Autism Spectrum Disorder
• Case-Control Studies
• Cerebral Cortex
• Linear Models
• Models, Biological
• Phenotype

Identifiers and source

Literature Corpus work

63916d8e-870a-5e84-9813-d365c4ae682b

DOI

10.21203/rs.3.rs-9647039/v1