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The Efficacy of Tumor Mutation Burden as a Biomarker of Response to Immune Checkpoint Inhibitors.

International journal of molecular sciences - 4 Apr 2023

Moeckel Camille, Bakhl Katrina, Georgakopoulos-Soares Ilias, Zaravinos Apostolos

Abstract excerpt

Cancer is one of the leading causes of death in the world; therefore, extensive research has been dedicated to exploring potential therapeutics, including immune checkpoint inhibitors (ICIs). Initially, programmed-death ligand-1 was the biomarker utilized to predict the efficacy of ICIs. However, its heterogeneous expression in the tumor microenvironment, which is critical to cancer progression, promoted the...

Topics

Humans
Immune Checkpoint Inhibitors
Mutation
Lung Neoplasms
Biomarkers, Tumor
Melanoma
Tumor Microenvironment

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 37047684
DOI: 10.3390/ijms24076710
PMCID: PMC10095310

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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