Article
Bis(morpholino-1,3,5-triazine) derivatives: potent adenosine 5'-triphosphate competitive phosphatidylinositol-3-kinase/mammalian target of rapamycin inhibitors: discovery of compound 26 (PKI-587), a highly efficacious dual inhibitor.
Journal of medicinal chemistry - 25 Mar 2010
Venkatesan Aranapakam M, Dehnhardt Christoph M, Delos Santos Efren, Chen Zecheng, Dos Santos Osvaldo, Ayral-Kaloustian Semiramis, Khafizova Gulnaz, Brooijmans Natasja, Mallon Robert, Hollander Irwin, Feldberg Larry, Lucas Judy, Yu Ker, Gibbons James, Abraham Robert T, Chaudhary Inder, Mansour Tarek S
Abstract excerpt
The PI3K/Akt signaling pathway is a key pathway in cell proliferation, growth, survival, protein synthesis, and glucose metabolism. It has been recognized recently that inhibiting this pathway might provide a viable therapy for cancer. A series of bis(morpholino-1,3,5-triazine) derivatives were p...
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