Article

Culture of human retinal explants as an ex vivo model for retinal gene therapy

2024-05-06

Abstract excerpt

Optogenetic gene therapy may employ recombinant adeno-associated virus (AAV) vectors for specific preclinical applications in the treatment of inherited retinal diseases. Human retinal explants as an ex vivo model assist determine cellular tropism and the level of subsequent gene expression followed by delivery of viral vectors. Extracts of retinal tissue can be obtained and cultured for a certain time; thus, it i...

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Literature Corpus work: 6272f2bd-df1c-5312-b311-5f03984f44d7
DOI: 10.1101/2024.05.06.592769

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